Collagen Induction Therapy
“Percutaneous Collagen Induction” (PCI) or “Collagen Induction Therapy” (CIT) is a skin treatment in which the outer layers of the skin, epidermis and dermis, are punctured in a minimally invasive manner, activating the body's own repair process and the renewal of damaged skin tissue by increasing collagen production. With the CIT, the wound healing mechanisms are activated without damaging the epidermis; the puncture channels close again quickly.
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The mechanism of Action

Step 1

Needle penetrates skin (Micro needle ø 0.1 mm)

- Release of thrombocytes & erythrocytes

- Spontaneous Reaction

- Release of growth signals & factors

Step 2

Pricking channels retract from 0.10 to 0.03 mm and less

- Invasion of erythrocytes and leucocytes

Step 3

Fibroblasts join the invasion of erythrocytes and leucocytes.

Synthesis of:




Collagen III

Step 4

New matrix components bolster up dermis from inside towards Surface and close pricking channels

- Tissue modulation

Wound Healing

1. Vascular Reaction

2. Blood Coagulation

3. Inflammation

4. New tissue formation

5. Epithelisation

6. Contraction

The change of scarring starts after the end of the contraction and take up to 12 months.


Rapid normalization of cell-to-cell communication (signaling) to improve cell function:

Neocollagenesis - Collageninductiontherapy (CIT)

Neo = new

Collagen = collagen

Genesis = generating/developing

Fibroblast cells differentiate to produce Collagen, Elastin and GAG’s. Myofibroblasts contract to add to the tightening effect.
Atraumatic needle

Using atraumatic needles enables the skin to seal very fast

Unlike most cases when tissues are injured, micro-needling does not cause fibroblasts to differentiate rapidly into myofibroblasts (myofibroblasts generate large contractions and actively produce extracellular matrix (ECM) proteins to facilitate wound closure)

How does Microneedling correct skin conditions?

Rapid normalization of cell-to-cell communication (signaling) to improve cell function:


Angio = vessel

Genesis = generating / developing

Angiogenesis is the physiological process through which new blood vessels form, out of pre-existing vessels. For example: stretch marks

Summary Microneedling